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Tocris Bioscience™ A 83-01
Selective inhibitor of TGF-βRI, ALK4 and ALK7
370.00€ - 1445.00€
Identificatori chimici
| CAS | 909910-43-6 |
|---|---|
| Formula molecolare | C25H19N5S |
| Peso molecolare | 421.522 |
| Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
|---|---|---|---|---|---|---|---|---|---|
| Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
|
18084932
|
Tocris Bioscience™
2939/10 |
10 mg |
370.00€
10mg |
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|
18025492
|
Tocris Bioscience™
2939/50 |
50 mg |
1445.00€
50mg |
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Description
Potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.Chemical Identifiers
| 909910-43-6 | |
| C25H19N5S | |
| 421.522 |
Specifications
| A 83-01 | |
| C25H19N5S | |
| >98% |
| 909910-43-6 | |
| 421.52 | |
| 421.522 |
Safety and Handling
Recommended Storage : Store at -20°C
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