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PIAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 13486-1-AP-20UL
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Descrizione
The PIAS3 antibody detects PIAS3 (68 kDa) as well as its sumoylated form (85 kDa) in some normal mouse tissues, breast and brain tumor cell lines.
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.Specifica
| PIAS3 | |
| Polyclonal | |
| Unconjugated | |
| PIAS3 | |
| E3 SUMO protein ligase PIAS3, PIAS3, ZMIZ5 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 10401, 229615, 83614 | |
| -20°C | |
| Liquid |
| Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 0.23 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O54714, O70260, Q9Y6X2 | |
| PIAS3 | |
| PIAS3 Fusion Protein Ag4304 | |
| 20 μL | |
| Primary | |
| Mouse, Human, Rat | |
| Antibody | |
| IgG |
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