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TCF7L2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Invitrogen PA522989

Codice prodotto. 13208258

  • 516.00€ / 100µL

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Descrizione

Descrizione

The target sequence has 93% sequence homology with mouse and bovine. Suggested positive control: TCF7L2 Overexpression lysate, Jurkat whole cell lysate.

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
TRUSTED_SUSTAINABILITY
Specifica

Specifica

TCF7L2
Polyclonal
Unconjugated
Tcf7l2
HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; mTcf-4B; mTcf-4E; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF4; TCF-4; TCF4B; TCF4E; Tcf7l2; TCF7L2 protein; transcription factor 7 like 2; transcription factor 7 like 2, T cell specific, HMG box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor Tcf4
Rabbit
Antigen affinity chromatography
RUO
6934
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
Q9NQB0
Tcf7l2
Synthetic peptide made to an internal portion of the human protein (within residues 150-200).
100 μL
Primary
Human
Antibody
IgG
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