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LIME Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Marca: Invitrogen PA19064
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Descrizione
This antibody is predicted to react with rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
Specifica
| LIME | |
| Polyclonal | |
| Unconjugated | |
| Lime1 | |
| 2810038K19Rik; dJ583P15.4; FLJ20406; Lck interacting transmembrane adaptor 1; lck-interacting membrane protein; Lck-interacting molecule; lck-interacting transmembrane adapter 1; Lime; lime 1; LIME1; LP8067; RP4-583P15.5 | |
| Goat | |
| Ammonium sulfate precipitation | |
| RUO | |
| 72699 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.5 mg/mL | |
| TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
| Q9EQR5 | |
| Lime1 | |
| Synthetic peptide corresponding to amino acids ENVYESIKEMGL. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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